Applications
RAB5A antibody has been tested by ELISA, ICC/IF and Western blot analysis to assure specificity and reactivity.
Reactivity
Human;Mouse;Rat;Hamster;Monkey
Immunogen
Anti-human RAB5A mAb is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with recombinant human RAB5A amino acids 1-215 purified from E. coli.
Background
RAB5A is a member of RAS oncogene family. The small GTPase, RAB5A is a crucial regulatory component of the endocytic pathway. Activation of RAB5A is mediated by GDP-GTP exchange factors (GEFs) that generate the Rab5-GTP complex). RAB5A is required for the fusion of plasma membranes and early endosomes.
References
[1] Zerial, M. and McBride, H. (2001) Nat Rev Mol Cell Biol 2, 107-17.
[2] van der Bliek, A.M. (2005) Nat Cell Biol 7, 548-50.
[3] Haas, A.K. et al. (2005) Nat Cell Biol 7, 887-93.
