ANGIOTENSIN I HUMAN ACETATE HYDRATE

Uses

Angiotensin I human acetate salt hydrate has been used:

• as an external calibration standard, it was applied to α-cyano-4-hydroxycinnamic acid (CHCA) and 2,5-dihydroxybenzoic acid (DHB) matrix,
• to prepare angiotensin I solution gravimetrically for hydrolysis and also used as a model peptide to demonstrate SI (système international) -traceable?amino acid analysis
• as an analyte to deposit on the target in the study of on-line single droplet deposition for matrix-assisted laser desorption/ionization (MALDI) mass spectrometry

General Description

Angiotensinogen (Angiotensin I) is a renin substrate, which is produced by the liver.

Biochem/physiol Actions

Angiotensin I is a putative neurotransmitter. It is the precursor of angiotensin II and of angiotensin fragment 1-7, which are the hormones involved in regulation of fluid volume and the release of aldosterone.

Purification Methods

Angiotensin is purified using extraction, affinity chromatography and HPLC [Hermann et al. Anal Biochem 159 295 1986].