Uses
Angiotensin I human acetate salt hydrate has been used:
- as an external calibration standard, it was applied to α-cyano-4-hydroxycinnamic acid (CHCA) and 2,5-dihydroxybenzoic acid (DHB) matrix,
- to prepare angiotensin I solution gravimetrically for hydrolysis and also used as a model peptide to demonstrate SI (système international) -traceableamino acid analysis
- as an analyte to deposit on the target in the study of on-line single droplet deposition for matrix-assisted laser desorption/ionization (MALDI) mass spectrometry
General Description
Angiotensinogen (Angiotensin I) is a renin substrate, which is produced by the liver.
Biochem/physiol Actions
Angiotensin I is a putative neurotransmitter. It is the precursor of angiotensin II and of angiotensin fragment 1-7, which are the hormones involved in regulation of fluid volume and the release of aldosterone.
Purification Methods
Angiotensin is purified using extraction, affinity chromatography and HPLC [Hermann et al. Anal Biochem 159 295 1986].
