4-[4-(1H-Imidazol-1-yl)phenyl]-N-2-propyn-1-yl-2-pyrimidinamine

Biological Activity

AP-C5 is a potent and selective inhibitor of the guanosine 3′,5′-cyclicmonophosphate (cGMP)-dependent protein kinase II (cGKII)th at selectively blocks cGKII dependent phosphorylation of the vasodilator-stimulated phosphoprotein (VASP) in intestinal organoids. AP-C5 mitigates secretory response provoked by the GCC-activating Escherichia coli heat-stable toxin (STa) in mouse small intestinal tissue.

storage

Store at -20°C