Description
(±)8(9)-DiHET-d11 is intended for use as an internal standard for the quantification of 8(9)-DiHET by GC- or LC-MS. 8(S),9(S)-DiHET and 8(R),9(R)-DiHET are vicinal diols formed via enzymatic hydration of 8(9)-EET by cytosolic or soluble epoxide hydrolases.1,2 8(S),9(S)-DiHET is produced at a greater proportion than 8(R),9(R)-DiHET by cytosolic epoxide hydrolase.1WARNING This product is not for human or veterinary use.
References
[1] D C ZELDIN. Regio- and enantiofacial selectivity of epoxyeicosatrienoic acid hydration by cytosolic epoxide hydrolase.[J]. The Journal of Biological Chemistry, 1993, 268 9: 6402-6407.
[2] GUODONG ZHANG Bruce D H Sean Kodani. Stabilized epoxygenated fatty acids regulate inflammation, pain, angiogenesis and cancer[J]. Progress in lipid research, 2014, 53: Pages 108-123. DOI:
10.1016/j.plipres.2013.11.003
