Description
14,15-Leukotriene A
4 (14,15-LTA
4) methyl ester is an esterified form of 14,15-LTA
4, a leukotriene isomer formed from arachidonic acid (Item Nos.
90010 |
90010.1 |
10006607) by 15-lipoxygenase (15-LO) that inhibits LTA
4 hydrolase.
Uses
14,15-Leukotriene A4 methyl ester (14,15-LTA4 methyl ester) is the methyl esterified form of Leukotriene A4, which can be used for the study of biological effects of leukotrienes[1][2].
References
[1] Wetterholm A, et al. 14,15-Dihydroxy-5,8,10,12-eicosatetraenoic acid. Enzymatic formation from 14,15-leukotriene A4. Eur J Biochem. 1988 May 2;173(3):531-6. DOI:
10.1111/j.1432-1033.1988.tb14031.x[2] Rao A V R, et al. Enantiospecific synthesis of 14S, 15S leukotriene A4 methyl ester[J]. Bioorganic & Medicinal Chemistry Letters, 1991, 1(4): 201-204.
