Chemical Properties
clear colorless to light yellow liquid
Uses
1-Methylpyrazole is a useful synthetic intermediate. It is used to synthesize heteroaryl(fluorophenyl)piperidinylindoles as α1 adrenoceptor antagonists. It is also used to prepare quinazoline derivatives as glucokinase activators.
Definition
ChEBI: A member of the class of pyrazoles that is the 1-methyl derivative of 1H-pyrazole.
Synthesis
1-Methylpyrazole was prepared by the condensation of 1,1,3,3-tetraethoxypropane with methylhydrazine[1].
References
[1] Peggy W. Alley, David A. Shirley. “The Metalation of 1-Phenyl- and 1-Methylpyrazole with n-Butyllithium.” Journal of the American Chemical Society 80 23 (1958): 6271–6274.
