LOLJEILMPWPILA-WZDCOHRSSA-N

Description

8-iso Prostaglandin F_2β (8-iso PGF_2β) is an isomer of PGF_2α of non-enzymatic origin. It is one of 64 possible isomers of PGF_2α which can be produced by free radical peroxidation of arachidonic acid. 8-iso PGF_2β exhibits very weak contraction of human umbilical vein artery and does not promote aggregation of human whole blood. However, 8-iso PGF_2β moderately contracts both the canine and porcine pulmonary vein, although the effect is much weaker than that exhibited by other isoprostanes such as 8-iso PGE₁, 8-iso PGE₂, or 8-iso PGF_2α. 8-iso-15-keto PGF_2β is a potential metabolite of 8-iso PGF_2β via the 15-hydroxy PG dehydrogenase pathway. There are no published reports on the formation or biological activity of 8-iso-15-keto PGF_2β.

Definition

ChEBI: 8-iso-15-keto Prostaglandin F2beta is a prostanoid.