Description
PtdIns-(3)-P1 can be further phosphorylated to give triphosphates such as PtdIns-(3,4,5)-P3. These can also be cleaved by PI-specific phospholipase C (PLC) to give inositol triphosphates (IP3). The diacyl glycerol and IP3 generated by this PLC-cleavage are also part of a complex biochemical and signal transduction cascade which has not been entirely elucidated. For some additional reading, please see references 1,2,3.WARNING This product is not for human or veterinary use.
References
[1] MAJERUS P W. Inositol phosphate biochemistry.[J]. Annual review of biochemistry, 1992, 61: 225-250. DOI:
10.1146/annurev.bi.61.070192.001301[2] L J PIKE L C. Localization and turnover of phosphatidylinositol 4,5-bisphosphate in caveolin-enriched membrane domains.[J]. The Journal of Biological Chemistry, 1996, 271 43: 26453-26456. DOI:
10.1074/jbc.271.43.26453[3] BERRIDGE M J. Inositol trisphosphate and calcium signalling[J]. Nature, 1993, 361 6410: 315-325. DOI:
10.1038/361315a0
