Anti-Spectrin, non-erythroid beta chain 1

Biological Activity

SPTBN1 (Spectrin β chain, non-erythrocytic 1) gene encodes a cytoskeletal protein th at interacts with α-synuclein and modulates neurite outgrowth. Its overexpression leads to excessive neurite formation from dopaminergic neuronal cell bodies. SPTBN1 may function as a tumor suppressor and its reduced expression has been correlated with reduced survival of pancreatic cancer patients.