Uses
Anti-Human Polyvalent Immunoglobulins (G,A,M) antibody produced in rabbit has been used in enzyme-linked immunosorbent assay (ELISA) and sandwich ELISA.
General Description
Immunoglobulin G (IgG) belongs to the immunoglobulin family and is a widely expressed serum antibody. IgG is usually found as a monomer. IgG antibody subtype is the most abundant of serum immunoglobulins of the immune system. About 70 percent of the total immunoglobulin consists of IgG. Immunoglobulin M (IgM ) is a high molecular weight protein that has five or six subunits. It is the first immunoglobulin produced by neonates.
Biochem/physiol Actions
Immunoglobulin M (IgM) acts as an antigen specific part of the B cell antigen receptor on the surface of B lymphocytes that are not stimulated, in its monomeric form. Polymeric IgM molecules also serve as important activators of the classical complement cascade. IgM is essential in agglutination and cytolytic reactions. Immunoglobulin G (IgG) participates in hypersensitivity type II and type III.
