L-Phenylalanine,N-(2-broMo-3-oxospiro[3.5]non-1-en-1-yl)-4-(2,7-naphthyridin-1-ylaMino)-,ethyl ester,sulfate (2:1

Uses

Zaurategrast ethyl ester sulfate (CDP323 sulfate), the ethyl ester proagent of CT7758[1], is a α4β1/α4β7 integrin antagonist used for the treatment of inflammatory and autoimmune disorders[2].

References

[1] Chanteux H, et al. Cross-Species Differences in the Preclinical Pharmacokinetics of CT7758, an α4β1/α4β7 Integrin Antagonist. Drug Metab Dispos. 2015 Sep;43(9):1381-91. DOI:10.1124/dmd.115.064436
[2] Davenport RJ, et al. Alpha4-integrin antagonism--an effective approach for the treatment of inflammatory diseases? Drug Discov Today. 2007 Jul;12(13-14):569-76. DOI:10.1016/j.drudis.2007.05.001