Uses
Reactant for:
- Preparation of cyclopentene fused benzofurans and indoles via Pd-catalyzed tandem ring opening-ring closing reaction with diazabicyclic alkenes
- Highly regioselective synthesis of spirocyclic compounds by a palladium-catalyzed intermolecular tandem reaction
- Regioselective synthesis of indene derivatives via Pd/C-catalyzed cyclization reaction in air
- Preparation of carbazoles via cross-coupling with silylaryl triflates followed by palladium-catalyzed cyclization
- Stereoselective preparation of heteropolycyclic compounds via palladium-catalyzed stereoselective heteroannulation of with cyclic alkenes
- Preparation of disubstituted coumarins via palladium-catalyzed carbonylative annulation of internal alkynes
- Preparation of arylalkynes, benzofurans and indoles via Sonogashira coupling and cyclization on alumina
Preparation
Preparation by reaction of iodine and potassium iodide on 4-hydroxyacetophenone in aqueous ammonium hydroxide at r.t. (54–57%).
Synthesis Reference(s)
Journal of Medicinal Chemistry, 23, p. 738, 1980
DOI: 10.1021/jm00181a008
