Uses
Anti-ORAI1 antibody produced in rabbit has been used in immunohistochemistry and Western blotting.
General Description
ORAI calcium release-activated calcium modulator 1 (ORAI1) is the pore-forming subunit of the Ca
2+ release-activated (CRAC) channel. The protein possesses four predicted transmembrane domains and intracellular amino and carboxyl-terminal domains. The ORAI1 gene is localized on human chromosome 12q24.31.
Biochem/physiol Actions
ORAI calcium release-activated calcium modulator 1 (ORAI1) modulates Ca2+ entry into cells. The channel is activated by stromal interaction molecule-1 (STIM-1). Mutation in the gene encoding the protein has been linked to late-onset tubular aggregate myopathy and congenital miosis.
