Low-dose (20 μg/kg) Glucagon increases glycemia and does not stimulate insulin secretion in ambient-fed mice. High-dose (1 mg/kg) Glucagon lowers glycemia compared with PBS control and stimulates insulin secretion in ambient-fed mice[4].
| Animal Model: | C57BL/6J mice (12- to 24-week-old)[4] |
| Dosage: | 20 μg/kg and 1 mg/kg |
| Administration: | Administered by i.p. injection; 45 minutes |
| Result: | Low-dose (20 μg/kg) increased glycemia and did not stimulate insulin secretion.
High-dose (1 mg/kg) lowered glycemia and stimulated insulin secretion. |
