Manufacturing Process
A mixture of 9.4 g of trans-4-guanidinomethylcyclohexanecarboxylic acid, 7.2
g of p-t-butylphenol and 10.0 g of dicyclohexylcarbodiimide was suspended in
a solution of 61 ml of dry pyridine and ml of dry dimethylformamide, and the
suspension was stirred at room temperature for 24 h.The solvent was
removed under reduced pressure.The residue was washed and dried.There
was obtained the 4’-t-butylphenyl trans-4-guanidinomethylcyclohexanecarboxylate.
In practice it is usually used as hydrochloride.
