Description
Omeprazole sulfone-d
3 is intended for use as an internal standard for the quantification of omeprazole sulfone by GC- or LC-MS. Omeprazole sulfone is the major metabolite of the gastric proton pump inhibitor, omeprazole . It is produced by cytochrome P450 (CYP)3A4 sulfoxidation of esomeprazole magnesium and is found in plasma.
1 Omeprazole sulfone has been shown to act as a reversible direct-acting and metabolism-dependent inhibitor of CYP2C19 in pooled human liver microsomes (IC
50 = 18 μM).
2
References
1. ?bel?, A., Andersson, T.B., Antonsson, M., et al.
Stereoselective metabolism of omeprazole by human cytochrome P450 enzymes Drug Metab. Dispos. 28(8),966-972(2000).
2. Ogilvie, B.W., Yerino, P., Kazmi, F., et al.
The proton pump inhibitor, omeprazole, but not lansoprazole or pantoprazole, is a metabolism-dependent inhibitor of CYP2C19: Implications for coadministration with clopidogrel Drug Metab. Dispos. 39(11),2020-2033(2011).
