Benzeneethanamine, 4-iodo-2,5-dimethoxy-N-[(2-methoxyphenyl)methylene]-, [N(E)]-

Description

25I-NBOMe, a derivative of the serotonin 2A (5-HT_2A) receptor agonist 2C-I, is 16-fold more potent than 2C-I with a K_i value of 0.044 nM for human 5-HT_2A receptors.^1,2 25I-NBOMe imine analog differs from 25I-NBOMe by having a double bond linking the N-(2-methoxybenzyl) group to 25I. The properties of this compound have not been evaluated. This product is intended for research and forensic applications.

References

1. Braden, M.R., Parrish, J.C., Naylor, J.C., et al. Molecular interaction of serotonin 5-HT_2A receptor residues Phe3396.51 and Phe3406.52 with superpotent N-benzyl phenethylamine agonists Mol. Pharm. 70(6),1956-1965(2006).
2. Ettrup, A., Palner, M., Gillings, N., et al. Radiosysnthesis and evaluation of ¹¹C-CIMBI-5 as a 5-HT_2A receptor agonist radioligand for PET J. Nucl. Med. 51(11),1763-1770(2010).