ChemicalBook CAS DataBase List 4'-Methylpropiophenone

4'-Methylpropiophenone

Product Name4'-Methylpropiophenone
CAS5337-93-9
CBNumberCB8116040
MFC10H12O
MW148.2
EINECS226-267-5
MDL NumberMFCD00009312
MOL File5337-93-9.mol
MSDS FileSDS

Chemical Properties

Melting point	7.2 °C
Boiling point	238-239 °C(lit.)
Density	0.993 g/mL at 25 °C(lit.)
refractive index	n20/D 1.528(lit.)
Flash point	229 °F
storage temp.	Inert atmosphere,Room Temperature
solubility	Soluble in chloroform and hexane.
form	Oil
color	Colourless
Specific Gravity	0.99
BRN	2042137
InChI	InChI=1S/C10H12O/c1-3-10(11)9-6-4-8(2)5-7-9/h4-7H,3H2,1-2H3
InChIKey	PATYHUUYADUHQS-UHFFFAOYSA-N
SMILES	C(C1=CC=C(C)C=C1)(=O)CC
CAS DataBase Reference	5337-93-9(CAS DataBase Reference)
FDA UNII	8490C17WAB
NIST Chemistry Reference	4'-Methylpropiophenone(5337-93-9)

Safety

Symbol(GHS)

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P301+P312-P302+P352-P304+P340-P305+P351+P338

Safety Statements

24/25

WGK Germany

HS Code

29143990

NFPA 704:

	1
0		0

4'-Methylpropiophenone Price

Product number	Packaging	Price	Product description	Buy
Sigma-Aldrich 517925	100ml	$47.34	4′-Methylpropiophenone 90%, technical grade	Buy
TCI Chemical M0768	25mL	$40	4'-Methylpropiophenone >95.0%(GC)	Buy
TCI Chemical M0768	500mL	$287	4'-Methylpropiophenone >95.0%(GC)	Buy
Alfa Aesar B21673	100g	$29.65	4'-Methylpropiophenone, 94%	Buy
Alfa Aesar B21673	500g	$121	4'-Methylpropiophenone, 94%	Buy

4'-Methylpropiophenone Chemical Properties,Usage,Production

Chemical Properties

clear light yellow liquid

Uses

4′-Methylpropiophenone is a chemical reagent used in electrocarboxylation reactions.

Uses

4'-methylpropiophenone has been reported to be used in the synthesis of pharmaceutical compounds such as tolperisone and other muscle relaxants. The substance is also a starting material in the synthesis of 4-methylmethcathinone (mephedrone). Mephedrone has been encountered as a ‘legal high’ and on the illicit drug market masquerading as cocaine (in powder form), MDMA (in tablet form) and as an adulterant. According to the 2016 European Drugs Market Report produced by the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA), mephedrone has created a specific demand and carved its own distinct market share.

Application

4′-Methylpropiophenone can be used as a building block to synthesize:
N-(4-Chlorophenyl)-N′-[1-(4-methylphenyl)propyl]urea as a potential CRAC channel inhibitor.
Mono and trinuclear cobaloxime/organocobaloxime complexes, which are used as efficient catalysts for the synthesis of cyclic carbonates.
Tolperisone (TOL) via acid-catalyzed reaction with piperidine hydrochloride and 1,2-dioxolane.

Definition

ChEBI: 4-methylpropiophenone is an aromatic ketone that is propiophenone bearing a methyl group at C-4. It derives from a propiophenone.

Synthesis

4'-Methylpropiophenone can be synthesized through various methods. One common approach involves the reaction of propiophenone with methylmagnesium bromide or methyl lithium in the presence of a catalyst. Another method utilizes Friedel-Crafts acylation, where propiophenone is acylated with methyl chloride or methyl bromide using a Lewis acid catalyst. These methods allow for the controlled introduction of the methyl group onto the phenyl ring.

4'-Methylpropiophenone synthesis

Preparation Products And Raw materials

4'-Methylpropiophenone Supplier

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12839	58
Shanghai Worldyang Chemical Co.,Ltd.	+86-021-56795779 +8613651600618	sales@worldyachem.com	China	1243	58
Dorne Chemical Technology co. LTD	+86-86-13583358881 +8618560316533	Ethan@dornechem.com	China	3095	58
HebeiShuoshengImportandExportco.,Ltd	+86-18532138899 +86-18532138899	L18532138899@163.com	China	939	58
Hebei Mojin Biotechnology Co.,Ltd	+86-15028179902	angelia@hbmojin.com	China	1177	58
Hebei Andu Technology Com.,Ltd	+86-86-17798073498 +8617798073498	admin@hbandu.com	China	299	58
SINO HIGH(CHINA)CO.,LTD.	+86-2558392388 +86-13914336446	chang@sinohighchem.com	China	34	58
Wuhan Boyuan Import & Export Co., LTD	+8615175982296	Mike@whby-chem.com	China	33	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5857	58
Nanjing Deda New Material Technology Co., Ltd	+8613223293093	bella@njdeda.com	China	80	58

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4'-Methylpropiophenone

Chemical Properties

Safety

4'-Methylpropiophenone Price

4'-Methylpropiophenone Chemical Properties,Usage,Production

4'-Methylpropiophenone synthesis

Preparation Products And Raw materials

4'-Methylpropiophenone Supplier

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