Metabolic pathway
A fluorinated fungicide [N-ethyl-N-methyl-4-
(trifluoromethyl)-2-(3,4-dimethoxyphenyl)benzamide
(EMTDB) is metabolized by plant cell cultures of Acer
pseudoplatanus, yielding approximately 10 fluorinated
metabolites observed in the cultures, five of which are
identified. The metabolism of EMTDB mostly occurs
through ring demethoxylation or mono O-
demethylation and N-dealkylation. The more lipophilic
derivatives diffuse into the culture medium; in contrast,
the more hydrophylic ones remain inside the cells.
