C18 D-threo Ceramide (d18:1/18:0)

Biological Activity

C18 D-threo Ceramide (d18:1/18:0) is a synthetic ceramide and stereoisomer of C18 ceramide .1 It inhibits rat brain mitochondrial ceramidase (mt-CDase) with an IC50 value of 16.6 μM.2 [Matreya, LLC. Catalog No. 1855]

References

1.Koolath, S., Murai, Y., Suga, Y., et al.Chiral combinatorial preparation and biological evaluation of unique ceramides for inhibition of sphingomyelin synthaseChirality32(3)308-313(2019) 2.Usta, J., El Bawab, S., Roddy, P., et al.Structural requirements of ceramide and sphingosine based inhibitors of mitochondrial ceramidaseBiochemistry40(32)9657-9668(2001)