Description
PNF1 (10442-95-2) is a novel small molecule inducer of angiogenesis which has been shown to be useful in tissue engineering applications.1 In a sustained release model, PNF1 promoted ingrowth and expansion of microvascular networks surrounding biomaterial implants.2 Its mechanism of action includes induction of TNF-α followed by TGF-β signaling and subsequent modulation of MMP14 (MT1-MMP) in human microvascular endothelial cells.3,4
References
Wieghaus et al. (2006) Small molecule inducers of angiogenesis for tissue engineering; Tissue Eng. 12 1903
Wieghaus et al. (2008) Expansion of microvascular networks in vivo by phthalimide neovascular factor 1 (PNF1); Biomaterials 29 4698
Wieghaus et al. (2008) Novel pathway compendium analysis elucidates mechanism of pro-angiogenic synthetic small molecule; Bioinformatics 24 2384
Wieghaus et al. (2009) Phthalimide neovascular factor 1 (PNF1) modulates MT1-MMP activity in human microvascular endothelial cells; Biotechnol. Bioeng. 103 796