Chemical Properties
2,3-dichlorophenol appears as light brown crystalline solid. Soluble in ether, chloroform and hot ethanol, insoluble in water and benzene.
Uses
2,3-Dichlorophenol is a chemical reagent used in the synthesis of a small molecule IL-2 inhibitor.
Preparation
2,3-Dichlorophenol is obtained from 1,2,3-trichlorobenzene by sulfonation to salt and high pressure hydrolysis to 3,4-dichloro-2-hydroxybenzenesulfonic acid, then hydrolyzed by sulfuric acid to remove the sulfonic acid group.
General Description
Brown crystals (from ligroin, benzene). Taste threshold concentration 0.00004 mg/L. Odor threshold concentration 0.03 mg/L.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
2,3-Dichlorophenol is incompatible with acid chlorides, acid anhydrides and oxidizing agents.
Fire Hazard
Flash point data for 2,3-Dichlorophenol are not available. 2,3-Dichlorophenol is probably combustible.
Purification Methods
Crystallise it from ether. [Beilstein 6 IV 883.]
