Uses
2,5-Dichloropyrimidine acid is employed as a important raw material and intermediate used in organic synthesis agrochemical, pharmaceutical and dyestuff field.
Preparation
2,5-Dichloropyrimidine was synthesised from 2-hydroxypyrimidine hydrochloride by treatment with
aqueous chlorine solution. Reaction of the product with
phosphoryl chloride in the presence of N,N-dimethylaniline gave the desired product in 40% yield. The sample was then
purified by sublimation.
storage
Store in cool, dry place in tightly closed container. With adequate ventilation. Store away from oxidizing agent.
structure and hydrogen bonding
C
4H
2Cl
2N
2, M=148.98 monoclinic, space
group P2
1/m with a=6.077(3), b=19.771(8), c=7.399(3)
?, β=101.23(6)°, U=872 ?
3 [from 2θ values of 29
reflections measured at±ω, 25 ≤2θ ≤ 38°, λ = 0.710 73?, T=150.0 K], D
calc=1.702 g cm
-3, Z=6, μ =0.993 mm-1[1].
References
[1] Blake A, et al. Structure Analysis Restrained by ab Initio Calculations: The Molecular Structure of
2,5-Dichloropyrimidine in Gaseous and Crystalline Phases. The Journal of Physical Chemistry, 1996; 100: 12280–12287.
