Description
Deltorphin C is a peptide agonist of δ-opioid receptors (Ki = 0.15 nM) that has been found in Phyllomedusa bicolor.1 It is selective for δ-opioid receptors over µ- and ĸ-opioid receptors. It induces δ-opioid receptor translocation from large dense-core vesicles to the cell surface and induces calcitonin gene-related peptide (CGRP) release in isolated mouse dorsal root ganglion (DRG) cells when used at concentrations of 0.1 and 1 µM, respectively, effects that can be blocked with the δ-opioid receptor antagonist naltrindole (Item No. 9000705).2 Intrathecal administration of deltorphin C (0.15, 1.5, and 15 µg/animal) increases latency to withdraw in the paw pressure and tail-flick tests in rats.3WARNING This product is not for human or veterinary use.
References
[1] V ERSPAMER. Deltorphins: a family of naturally occurring peptides with high affinity and selectivity for delta opioid binding sites.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1989, 86 13: 5188-5192. DOI:
10.1073/pnas.86.13.5188[2] LAN BAO. Activation of delta opioid receptors induces receptor insertion and neuropeptide secretion.[J]. Neuron, 2003, 37 1: 121-133. DOI:
10.1016/s0896-6273(02)01103-0[3] D LABUZ . Antinociceptive effects of isoleucine derivatives of deltorphin I and deltorphin II in rat spinal cord: a search for selectivity of delta receptor subtypes[J]. Neuropeptides, 1998, 32 6: Pages 511-517. DOI:
10.1016/s0143-4179(98)90079-8
