Background
Glutathione S-transferase Mu 1, encoded by GSTM1, belongs to the superfamily of glutathione-S transferases. It is a phase 2 enzyme involved in the inactivation of reactive oxygen species and metabolism of xenobiotics, using glutathione and generating oxidized glutathione. Polymorphisms of the gene have been associated with nasopharyngeal cancer, laryngeal cancer, colorectal cancer, hypertension, and chronic kidney disease. In the brain, GSTM1 contributes to astrocyte-mediated enhancement of microglia activation during brain inflammation as it is required for nuclear factor κB activation and proinflammatory mediator production.
References
[1] Levy, R. and Le, T.H. (2022) Kidney 360 3, 2153-2163.
[2] Zhang, F. et al. (2017) Onco Targets Ther 10, 1433-1440.
[3] Song, L. et al. (2020) Biosci Rep 40, BSR20201927. doi: 10.1042/BSR20201927.
[4] Kano, S.I. et al. (2019) Sci Signal 12, eaar2124. doi: 10.1126/scisignal.aar2124.
