Applications
The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Recommended starting dilution is 1:1000.
Immunogen
Anti-human SAR1B mAb, clone PAT1C7A, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human MRRF protein 1-198 amino acids purified from E. coli.
Background
SAR1B is a small GTPase that functions as a homodimer. GTP-Binding Protein SAR1B (SAR1b) is involved in transport from the endoplasmic reticulum to the Golgi apparatus and also in the selection of the protein cargo and the assembly of the COPII coat complex. The SAR1B protein is activated by the guanine nucleotide exchange factor PREB. SAR1B gene defects are a cause of chylomicron retention disease (CMRD), also known as Anderson disease (ANDD).
