General Description
A cell-permeable pyrazole derivative that acts as a selective blocker of the transient receptor potential cation channel TRPC3-medated ROCE (receptor-operated Ca
2+ entry) and inhibits Carbachol- (Cat. No.
212385) induced Ca
2+ entry in TRPC3-expressing HEK293 cells (IC
50 = 0.72 μM; by Fura-2; peak current density pA/pF = -1.01 and -18.50, respectively, with or without 3 μM Pyr10 by whole cell clamp), while exhibiting much reduced potency against Stim1 and Orai1-coupled CRAC (Ca
2+ release-activated Ca
2+) channel-mediated SOCE (store-operated Ca
2+ entry) in RBL-2H3 cells (IC
50 = 13.08 μM; by Fura-2; pA/pF = -4.39 and -7.50, respectively, with or without 3 μM Pyr10). A great complement to Pyr2 (Cat. No.
203890), Pyr 3 (Cat. No.
648490), and Pyr6 (Cat. No.
203891) in Ca
2+ signaling studies.
