Applications
Staining antibody. For staining, use 10µl/1,000,000 cells.
Background
CD44 is a cell-surface glycoprotein that plays a role in cell-cell interactions, cell adhesion and migration. CD44 is a receptor for hyaluronic acid and also interacts with other ligands, such as osteopontin, collagens, and matrix metalloproteinases. CD44 participates in a wide variety of cellular functions such as lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis.
CD44 and CD49d are putative activity markers and CD44 a potential novel therapeutic target in multiple sclerosis. Increased CD44 antigen is associated with relapses in non-small cell lung cancers.
References
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[4] Legg, J.W. et al. (2002) Nat. Cell Biol. 4, 399-407.
[5] Yonemura, S. et al. (1998) J. Cell Biol. 140, 885-895.
[6] Tsukita, S. et al. (1994) J. Cell Biol. 126, 391-401.
