Uses
Anti-hnRNP-A1 has been used in immunofluorescence, immunohistochemistry and western blotting.
Does not immunoprecipitate the hnRNP complex.
General Description
hnRNP-A1 (heterogeneous nuclear ribonucleoprotein) is a pre-mRNA/mRNA binding protein, that belongs to the hnRNP family. It is located in chromosome 12q13.1. It is located in the nucleoplasm but it travels between the nucleus and the cytoplasm. It has two RNP motif RNA-binding domains (RBDs) at the amino terminus and a glycine-rich domain at the carboxyl terminus.
Biochem/physiol Actions
hnRNP-A1 (heterogeneous nuclear ribonucleoprotein) participates in several RNA metabolisms. It also participates in deep vein thrombosis patients with beh?et′s disease. hnRNPA1 mutations results in amyotrophic lateral sclerosis and multisystem proteinopathy.