Uses
1,1-Diethoxypentane-d10 is a deuterated labeled 1,1-Diethoxypentane[1].
Definition
ChEBI: 1,1-Diethoxypentane is an acetal.
Preparation
To a flask equipped as in Preparation 2-23 and containing 137.5 ml (0.3 mole) of etheral n-butylmagnesium bromide is added dropwise 58.9 gm (0.3 mole) of diethyl phenyl orthoformate dissolved in 120 ml of ether. The reaction is exothermic and causes the ether to reflux and precipitate a colorless precipitate. The reaction mixture is refluxed for ½hr, added to 30% aqueous ammonium chloride, extracted with 200 ml of ether, washed with water, dried, and distilled to afford 43.5 gm (90.5%), b.p. 50°C (9 mm Hg).
References
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:
10.1177/1060028018797110
