N-(Amino-PEG4)-N-Biotin-PEG4-acid

Description

N-(Amino-PEG4)-N-Biotin-PEG4-acid is a 3-arm biotinylation reagent with terminal amine(NH2) and carboxylic acid moieties. The amine group can react with activated NHS esters. Carboxylic acid can conjugate with primary amines in the presence of activators such as EDC or HATU to form stable amide bonds.

Uses

N-(Amino-PEG4)-N-Biotin-PEG4-acid is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521. DOI:10.1038/nchembio.2329