AlPhos

Reaction

1. Ligand for the Palladium-Catalyzed Fluorination of Five-Membered Heteroaryl Bromides
2. Ligand for the Palladium-Catalyzed Fluorination of Aryl Triflates and Bromides

Uses

AlPhos is used in the selective arylation of aminophenylalanine in unprotected peptides with organometallic palladium reagents.

General Description

AlPhos is a versatile, highly efficient ligand used extensively in various important organic transformations. Recognized for its unique structure and attributes, AlPhos serves as an impressive catalyst that enables several key synthetic processes. It is primarily used in the following coupling reactions: Buchwald-Hartwig cross coupling, Suzuki-Miyaura coupling, Stille coupling, Sonogashira coupling, Negishi coupling, Heck coupling, Hiyama coupling reaction. With its remarkable performance across these reactions, AlPhos represents an invaluable tool in preparing and producing pharmaceuticals, agrochemicals, and polymers.