COX-2 INHIBITOR I

Definition

ChEBI: LM-1685 is an indolyl carboxylate ester that is methyl 1H-indole-2-carboxylate substituted by a 4-chlorobenzyl group at position 1 and a methylsulfonyl group at position 5. It acts as a selective inhibitor of cyclooxygenase 2. It has a role as a cyclooxygenase 2 inhibitor. It is an indolyl carboxylate ester, a sulfone, a member of monochlorobenzenes and a methyl ester.

Biological Activity

Cell permeable: yes', 'Primary Target
COX-2 from human monocytes', 'Product does not compete with ATP.', 'Reversible: no', 'Target IC50: 650 nM against COX-2 from human monocytes; 4.3 μM against COX-2 in whole blood