Description
Ald-Ph-PEG4-t-butyl ester contains a benzaldehyde group which can react with aminooxy (ONH2) bearing molecules. The t-butyl ester is a protecting group that can be removed under acidic conditions for further conjugation, PEG space improve aqueous solubility.
Uses
Ald-Ph-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:
10.1016/j.ebiom.2018.09.005
