cholestanol, 5α,6α-epoxy-d7

Uses

Isotope labelled isomer of Cholesterol 5β,6β-epoxide is an oxysterol produced as an oxidation product of cholesterol.

Biological Activity

5α,6α-epoxycholestanol (5α,6α-EC) is a liver X receptor (LXR) antagonist. 5α,6α-EC is employed in anticancer treatments. It impairs redox state and affects atherogenesis. The levels of 5α,6α-EC are elevated in hypercholesterolemia. It mediates steroid receptor coactivator (SRC) recruitment.