ChemicalBook > CAS DataBase List > (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine

(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine

(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine Structure
(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine
  • CAS No.314771-76-1
  • Chemical Name:(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine
  • CBNumber:CB72617898
  • Molecular Formula:C18H16ClFN4O2
  • Formula Weight:374.8
  • MOL File:314771-76-1.mol
(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine Property
  • Boiling point: :559.0±50.0 °C(Predicted)
  • Density  :1.473±0.06 g/cm3 (20 ºC 760 Torr)
  • storage temp.  :Keep in dark place,Inert atmosphere,Room temperature
  • pka :5.89±0.30(Predicted)
  • FDA UNII :Q58L53U44Y
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine Price More Price(15)
  • Brand: TRC
  • Product number: A355320
  • Product name : Afatinib-des(4-dimethylamino-2-en-1-oxo)butyl(Contained~8.5%Ethanol)
  • Purity: 
  • Packaging: 10g
  • Price: $870
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Matrix Scientific
  • Product number: 090075
  • Product name : (S)-N4-(3-Chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
  • Purity: 95+%
  • Packaging: 1g
  • Price: $1647
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: American Custom Chemicals Corporation
  • Product number: CCH0033466
  • Product name : (S)-N4-(3-CHLORO-4-FLUOROPHENYL)-7-((TETRAHYDROFURAN-3-YL)OXY)QUINAZOLINE-4,6-DIAMINE
  • Purity: 95.00%
  • Packaging: 250MG
  • Price: $475.65
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: AK Scientific
  • Product number: 3400AB
  • Product name : (S)-N4-(3-Chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
  • Purity: 
  • Packaging: 25g
  • Price: $721
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Matrix Scientific
  • Product number: 090075
  • Product name : (S)-N4-(3-Chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
  • Purity: 95+%
  • Packaging: 250mg
  • Price: $742
  • Updated: 2021/12/16
  • Buy: Buy

(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine Chemical Properties,Usage,Production

  • Uses (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diamine can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
  • Chemical Synthesis To a solution of 4-(3-chloro-4-fluorophenyl)amino-6-nitro-7-[[(S)-tetrahydro-3-furanyl]oxy]- quinazoline (1.34 g, 3.31 mmol) and ammonium chloride (496 mg, 9.27 mmol) in anhydrous DMF (22 mL), Raney nickel [1.5 mL, 50 % (w/v) in water] was added to the reaction mixture and stirred under an atmosphere of hydrogen at 40 °C for 2 h. After 2 h the reaction was diluted with EtOH (10 mL), filtered through diatomaceous earth and washed with a large excess of EtOH. The residue was concentrated under reduced pressure and purified by column chromatography eluting with CHCl3/MeOH (95:5) to give 6 as a viscous brown oil (950 mg, 77 %).
(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine Preparation Products And Raw materials
Raw materials
Preparation Products
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314771-76-1, (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMineRelated Search:
  • 4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-amine-7-[[(3S)-tetrahydro-3-furanyl]oxy]-
  • 6-Amino-4-[(3-chloro-4-fluorophenyl)amino]-7-[[(S)-tetrahydro-3-furanyl]oxy]quinazoline
  • Afatinib-1
  • (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diammine
  • 4,6-Quinazolinediamine, N4-(3-chloro-4-fluorophenyl)-7-[[(3S)-tetrahydro-3-furanyl]oxy]-
  • Afatinib-des(4-dimethylamino-2-en-1-oxo)butyl
  • N4-(3-Chloro-4-fluorophenyl)-7-[[(3S)-tetrahydro-3-furanyl]oxy]-4,6-quinazolinediamine
  • Intermediates of sunitinib
  • (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine
  • 7-((S)-tetrahydrofuran-3-yloxy)-4-(3-chloro-4-fluorophenyl) aMino-6-aMinoquinazoline
  • Afatinib IMpurity B
  • Afatinib intermediate D
  • N4-(3-Chloro-4-fluorophenyl)-7-[[(3S)-tetrahydro-3-furanyl]
  • Afatinib INT
  • 4-N-(3-chloro-4-fluorophenyl)-7-[(3S)-oxolan -3-yl]oxyquinazoline-4,6-diamine
  • (S)-N-(3-Chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
  • S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4
  • 3-furanyl]oxy]-4,6-quinazolinediamine
  • (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diammine fandachem
  • (S)-N4-(3-chloro-4-fluoro-phenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diamine fandachem
  • Afatinib Impurity 1 ABCDEFGHJKL
  • (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine ISO 9001:2015 REACH
  • (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diamie
  • 314771-76-1
  • Afatinib Dimaleate