Description
The TP receptor is a G protein-coupled receptor that mediates the action of thromboxane A
2 (TXA
2). Alternative splicing of
TP pre-mRNA produces two receptor variants, TP
α and TP
β, which differ in sequence and the length of their carboxy terminal tail. TP receptors are expressed primarily in platelets but are also expressed in placenta, vascular smooth muscle, brain, small intestine, thymus, kidney, lung, spleen, and monocytes. It signals in a cell type- and expression-dependent manner and has roles in cardiovascular and hemodynamic function.
Tp-/- mice exhibit coagulation defects, altered vascular responses to TXA
2 and arachidonic acid, and increased susceptibility to arachidonic acid-induced shock. Cayman’s TP Receptor (mouse) Polyclonal Antibody can be used for Western blot (WB). The antibody recognizes the TP
α and TP
β receptors from human, bovine, monkey, mouse, and rat samples. The apparent molecular weight for TP receptors has been reported from 37 kDa to 70 kDa, depending on different degrees of glycosylation.
