Description
The Cayman COX Inhibitor Pack contains a combination of frequently used cyclooxygenase (COX) inhibitors. Each kit contains aspirin, the archetype nonselective, irreversible COX inhibitor. A series of COX-
2 selective inhibitors are available in the COX-
PAK, including NS-
398, one of the first reported and most widely used. Another COX-
2-
selective inhibitor included is CAY10404, with nearly 500,000-
fold COX-
2 selectivity. The potent COX-
1-
selective inhibitor SC-
560 is an example of a reversible, diaryl heterocycle COX-
1 inhibitor with low nM activity. Also included is valeroyl salicylate, an irreversible alkylator of COX enzymes with some selectivity toward COX-
1. Resveratrol is also included in the COX-
PAK due to its complex activities, which include COX inhibition, peroxidase inhibition, antioxidant activity, and gene regulation.
