Description
Epoxyeicosatrienoic acids (EETs), such as 11(12)-
EET and 14(15)-
EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-
derived hyperpolarizing factors with vasodilator activity. 14,15-
EE-
5(Z)-
E is a structural analog of 14,15-
epoxyeicosatrienoic acids (14,15-
EET) that antagonizes EET-
induced relaxation of vascular smooth muscle. Relaxation of U46619-
constricted bovine arteries by 14,15-
EET could be inhibited approximately 80% by 14,15-
EE-
5(Z)-
E at a concentration of 10 μM. 14,15-
EE-
5(Z)-
E does not appear to antagonize nitric oxide-
or iloprost-
mediated vascular relaxation.