10-(1,3-Benzodioxol-5-yl)furo[3',4':6,7]naphtho[1,2-d]-1,3-dioxol-7(9H)-one

Definition

ChEBI: Helioxanthin is a furonaphthodioxole that is furo[3',4':6,7]naphtho[1,2-d][1,3]dioxol-7(9H)-one substituted by a 1,3-benzodioxol-5-yl group at posiiton 10. It is a inhibitor of HBV, HCV and HSV-1 viruses. It has a role as an anti-HBV agent, a plant metabolite and an antineoplastic agent. It is a member of benzodioxoles, a furonaphthodioxole and a lignan.

Biological Activity

helioxanthin (ach126447) is a novel inhibitor of hbv, hcv and hsv-1 virus with ec50 values of 1 μm, 3 μm and 2 μm, respectively [1].helioxanthin has shown significant antiviral effect on hbv, hcv and hsv-1 virus in vitro with ec50 values of 1 μm, 3 μm and 2 μm, respectively. in a cell culture model, the level of hbv rna, the expression of hbv antigen and its replication were all reduced by helioxanthin. besides, helioxanthin has been exhibited to have a low cytotoxicity on both mt-223 and cem24 cell lines with id50 values of 2.5 μm and 31 μm, respectively [1].

References

[1] yeo h1, li y, fu l, zhu jl, gullen ea, dutschman ge, lee y, chung r, huang es, austin dj, cheng yc. synthesis and antiviral activity of helioxanthin analogues. j med chem. 2005 jan 27;48(2):534-46.