Casein kinase 1δ-IN-31

Uses

Casein kinase 1δ-IN-31 (Compound 16) is the inhibitor for casein kinase (CK) that inhibits CK1α, CK1δ, and p38α with IC50s of 196, 17, and 18 nM, respectively. Casein kinase 1δ-IN-31 inhibits Double Homeobox 4 (DUX4) with IC50 of 1200 nM[1].

IC 50

CK1δ: 17 nM (IC₅₀); p38α: 18 nM (IC₅₀); CK1α: 196 nM (IC₅₀)

References

[1] Maeyer JD, et al., Casein kinase 1 inhibitors for use in the treatment of diseases related to dux4 expression such as muscular dystrophy and cancer. WO2020249717