ANTI-EPITHELIAL MEMBRANE ANTIGEN
- Product NameANTI-EPITHELIAL MEMBRANE ANTIGEN
- CAS
- CBNumberCB7157325
- MW0
- MDL NumberMFCD00211919
- MOL FileMol file
Chemical Properties
storage temp. | −20°C |
ANTI-EPITHELIAL MEMBRANE ANTIGEN Price
Product number | Packaging | Price | Product description | Buy |
---|---|---|---|---|
Sigma-Aldrich E0143 | 0.2mL | $398 | Monoclonal Anti-Episialin (EMA) antibody produced in mouse clone GP1.4, ascites fluid |
Buy |
American Custom Chemicals Corporation ATB0011533 | 5MG | $498.53 | ANTI-EPITHELIAL MEMBRANE ANTIGEN-HUMAN 95.00% |
Buy |
ANTI-EPITHELIAL MEMBRANE ANTIGEN Chemical Properties,Usage,Production
Uses
Cell-membrane-associated, mucin-like molecules, such as episialin has a protective function against toxic substances. Data on the effect of episialin on the adhesion properties of cultured cells suggests that episialin expressed at high levels on cells may have a major function in reducing the aggregation capacity of these cells, thus influencing the adherence to various extracellular matrix components by masking adhesion molecules.General Description
Monoclonal Anti-Episialin (EMA) (mouse IgG1 isotype) is derived from the GP1.4 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse.Biochem/physiol Actions
Episialin is a transmembrane, high molecular weight, mucin-like glycoprotein (apparent molecular weight of 265-400 kDa) containing many carbohydrate side chains, that are predominantly attached to the molecule by O-glycosidic linkages. It is known as epithelial membrane antigen (EMA), MUC1 and polymorphic epithelial mucin (PEM). The episialin molecule is transmembranous with a relatively large extracellular domain and a cytoplasmic domain of 69 amino acids. The extracellular domain consists mainly of a region of nearly identical repeats of 20 amino acids, the number of which can vary between about 30 and 90 because of genetic polymorphism. The episialin molecule is synthesized as one large precursor containing only N-linked glycans and is immediately proteolytically cleaved while still in the endoplasmic reticulum.Preparation Products And Raw materials
ANTI-EPITHELIAL MEMBRANE ANTIGEN Suppliers
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