RU 58668

Uses

RU 58668 is a pure antiestrogen.

Definition

ChEBI: A 17beta-hydroxy steroid that is 17beta-estradiol in the the hydrogen at the 11beta position has been replaced by a p-({5-[(4,4,5,5,5-pentafluoropentyl)sulfonyl]pentyl}oxy)phenyl group. RU 586 8 is a pure anti-estrogen that downregulates estrogen receptor expression (IC50 = 0.04 nM).

Biological Activity

Pure antiestrogen that downregulates estrogen receptor expression (IC 50 = 0.04 nM). Displays potent antiproliferative activity in vitro (IC 50 = 0.035 - 0.09 nM in MCF-7 cells) and causes long term regression of tamoxifen-resistant MCF-7 xenografts in vivo .