General Description
Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol (GPI)-anchored protein. The gene encoding it is localized on human chromosome 8q24. PSCA is a 123 amino acid protein, belonging to the thymocyte antigen 1 family.
Biochem/physiol Actions
Prostate stem cell antigen (PSCA) regulates the cell cycle, has a role in signal transduction pathways and mediates c-Myc-stimulated proliferation. It may have a role in prostate cancer. PSCA has been shown to be expressed in various cancers.
