Uses
Aristolocholic acid for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Hazard
Suspected carcinogen.
Biochem/physiol Actions
Component of some Chinese herbal medicines, and responsible for their nephrotoxicity. Prodrug activated by reduction of the nitro group to an amine, which forms cytotoxic DNA adducts.
Safety Profile
Suspected carcinogen. Mutation data reported. When heated to decomposition it emits toxic vapors of NOx.
