Pentanoic acid, 5-[[(1S)-2-[(acetyloxy)methoxy]-1-methyl-2-oxoethyl]amino]-5-oxo-, methyl ester

Uses

Pro-GA is a γ-Glutamylcyclotransferase (GGCT) inhibitor and a cell-permeable diester-type pro-drug with anticancer activity, GGCT is a key enzyme in glutathione metabolism and is involved in the ferroptosis pathway. Pro-GA exhibits an IC50 of 57 μM against the bladder cancer cell line T24 and can be utilized in cancer research[1].

References

[1] Hanada E, et al. Pro-GA, a Novel Inhibitor of γ-Glutamylcyclotransferase, Suppresses Human Bladder Cancer Cell Growth. Anticancer Res. 2019 Apr;39(4):1893-1898. DOI:10.21873/anticanres.13297