Benzonitrile, 3-[4-amino-5-fluoro-6-[1-[[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]methyl]-1H-1,2,3-triazol-4-yl]-2-pyrimidinyl]-2-methyl-

Description

Adenosine receptor antagonist 2 is an orally active A2a/A2b adenosine receptor antagonist with IC₅₀s of 1 nM and 3 nM, respectively. Adenosine receptor antagonist 2 has anti-tumor activity^[1].

Adenosine receptor antagonist 2 (compound L-1; po; 10, 30, 100 mg/kg; twice a day for 22 days) inhibits tumor growth in female C57BL / 6mice mice with MC38(#22)-hpd-L1 cells^[1].
Adenosine receptor antagonist 2 (iv; 2 mg/kg) has a CLz of 14.7 mL/min.kg and an AUC of 2252 h.ng/mL. Adenosine receptor antagonist 2 (po; 10 mg/kg) has a C_max of 8730 ng/mL in adult male ICR mice (weight 25-40g)^[1].