Andecaliximab
- Product NameAndecaliximab
- CAS1518996-49-0
- CBNumberCB68080925
- MW0
- MOL FileMol file
- MSDS FileSDS
Andecaliximab Price
| Product number | Packaging | Price | Product description | Buy |
|---|---|---|---|---|
| ChemScene CS-0621475 | 1mg | $325 | Andecaliximab 98.57% |
Buy |
| ChemScene CS-0621475 | 5mg | $845 | Andecaliximab 98.57% |
Buy |
| ChemScene CS-0621475 | 10mg | $1354 | Andecaliximab 98.57% |
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| ChemScene CS-0621475 | 25mg | $2492 | Andecaliximab 98.57% |
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| Biorbyt Ltd orb1980587 | 1mg | $290 | Andecaliximab Antibody >95% |
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Andecaliximab Chemical Properties,Usage,Production
Uses
Andecaliximab is a recombinant chimeric IgG4 monoclonal antibody (mAb) targets matrix metalloproteinase 9 (MMP9). Andecaliximab shows the antifibrotic efficacy in idiopathic pulmonary fibrosis mouse models. Andecaliximab can be used for the research of gastric adenocarcinoma and idiopathic pulmonary fibrosis (IPF)[1][2].in vivo
Andecaliximab improves T-cell receptor (TCR) diversity (decreased clonality) within tumor-infiltrating T-cell[1]. Andecaliximab (20 mg/kg; i.p. once) shows the antifibrotic efficacy in a humanized NSG mouse model of idiopathic pulmonary fibrosis[2].
| Animal Model: | Humanized nonobese diabetic, SCID, IL-2 receptor g (NSG) mouse model of IPF[2] |
| Dosage: | 20 mg/kg |
| Administration: | Intraperitoneal injection; 20 mg/kg, once a week for once |
| Result: | Decreased SMAD2 phosphorylation and increased surfactant protein C. Reduced MMP9+ cells, including MMP9+, CCR10+ and MMP9+CD45- and EpCAM+CCR10+ subpopulations. |
References
[1] Andrew E. Greenstein, et al. Effect of andecaliximab (anti-MMP9) on proteolysis of IL-7 in vitro, TCR diversity in mice, and serum IL-7 in gastric cancer patients in combination with chemotherapy. 2018 ASCO-SITC Clinical Immuno-Oncology Symposium.[2] Espindola MS, et al. Differential Responses to Targeting Matrix Metalloproteinase 9 in Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2021 Feb 15;203(4):458-470. DOI:10.1164/rccm.201910-1977OC
Preparation Products And Raw materials
Andecaliximab Suppliers
Global(23)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
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| 18007167883 18007167883 |
Service@mabnus.com | China | 921 | 58 | |
| 18916372613 | yanzihan@shyuanye.com | China | 87240 | 60 | |
| 177-54423994 17754423994 |
2853530910@QQ.com | China | 7999 | 62 | |
| 15817493340 | 981810490@qq.com | China | 1577 | 58 | |
| 027-65317797 15926423062 |
422450190@qq.com | China | 10300 | 58 | |
| 010-60605840 | psaitong@jm-bio.com | China | 27756 | 58 | |
| 4008200310 15002144251 |
marketing@tsbiochem.com | China | 24951 | 58 | |
| 027-65279366 18108604356 |
products@biolabreagent.com | China | 9864 | 58 | |
| 13720134139 086-15871494362 13720134139 |
orders@jknbiochem.com | China | 7353 | 58 | |
| 021-65675885 18964387627 |
customer_service@efebio.com | China | 11963 | 58 |
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