Thalidomide-NH-C4-NH2 TFA
- Product NameThalidomide-NH-C4-NH2 TFA
- CAS2093387-50-7
- CBNumberCB66127051
- MFC19H21F3N4O6
- MW458.39
- MDL NumberMFCD32903491
- MOL File2093387-50-7.mol
Thalidomide-NH-C4-NH2 TFA Chemical Properties,Usage,Production
Biological Activity
Thalidomide-NH-C4-NH2 TFA (compound 29c) is an E3 ligase ligand-linker conjugate, and incorporates the Thalidomide based cereblon ligand and a linker. Thalidomide-NH-C4-NH2 TFA is used in PROTAC BRD2/BRD4 degrader-1 . PROTAC BRD2/BRD4 degrader-1 is a potent and selective BET protein BRD4 and BRD2 degrader[1].References
[1]. Jiang F, et al. Discovery of novel small molecule induced selective degradation of the bromodomain and extra-terminal (BET) bromodomain protein BRD4 and BRD2 with cellular potencies. Bioorg Med Chem. 2020 Jan 1;28(1):115181.Preparation Products And Raw materials
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