Background
COX10 is an assembly factor for cytochrome c oxidase in the mitochondrial electron transport chain. Studies show that, when the gene encoding the β2-adrenergic receptor is deleted, increased oxidative phosphorylation in endothelial cells inhibits angiogenesis. Deletion of Cox10 prevents the metabolic switch to oxidative phosphorylation in endothelial cells deleted of Adrb2, causing angiogenesis and cancer progression. In addition, COX10 contributes to T cell quiescence exit and is critical for T cell activation.
References
[1] Tarasenko, T.N. et al. (2017) Cell Metab 25, 1254-1268.e7.
[2] Zahalka, A.H. et al. (2017) Science 358, 321-326.
[3] Tan, H. et al. (2017) Immunity 46, 488-503.
